3-Nitroaniline → 3-chloro-N-(3-nitrophenyl)propanamide

HRID 1076933노트

반응식

HRID 1076933 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7])([O-:3])=[O:2].[Cl:11][CH2:12][CH2:13][C:14](Cl)=[O:15]>C1C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[C:6]([NH:7][C:14](=[O:15])[CH2:13][CH2:12][Cl:11])[CH:8]=[CH:9][CH:10]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 74233-NitroanilineHCID 693643-Chloropropionyl chloride

생성물 1

HCID 34652363-chloro-N-(3-nitrophenyl)propanamide

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

3-Nitroaniline (0.3 moles), β-chloropropionyl chloride (0.35 mole) and benzene (100 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at reflux with stirring for a period of about 4 hours. After this time the reaction mixture is cooled to room temperature and is washed with dilute aqueous sodium bicarbonate, with dilute hydrochloric acid and with water. The washed mixture is then dried over anhydrous magnesium sulfate, filtered and stripped of benzene under reduced pressure to yield the desired product N-(3-nitrophenyl)-β-chloropropionamide as the residue.

후처리

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThe reaction mixture is heated
  4. temperatureat reflux
  5. washis washed with dilute aqueous sodium bicarbonate, with dilute hydrochloric acid and with water
  6. dry with materialThe washed mixture is then dried over anhydrous magnesium sulfate
  7. filtrationfiltered

출처 및 근거

ORD 기록
ord-cebbaf73f2b042388e05a7eb70012b52
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03958974

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