21-Bromo-5alpha-pregnane-3,11,20-trione → 21-Morpholinoacetylthio-5alpha-pregnane-3,11,20-trione

HRID 1077024노트

반응식

HRID 1077024 반응식
Br[CH2:2][C:3](=[O:25])[C@@H:4]1[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C:19](=[O:23])[CH2:20]2)[C@:16]2([CH3:17])[C@H:11]([CH2:12][C:13](=[O:24])[CH2:14][CH2:15]2)[CH2:10][CH2:9]3)[CH2:6][CH2:5]1.[O:26]1[CH2:31][CH2:30][N:29]([CH2:32][C:33]([OH:35])=[S:34])[CH2:28][CH2:27]1>CC(C)=O>[O:26]1[CH2:31][CH2:30][N:29]([CH2:32][C:33]([S:34][CH2:2][C:3](=[O:25])[C@@H:4]2[C@:21]3([CH3:22])[C@H:7]([C@H:8]4[C@H:18]([C:19](=[O:23])[CH2:20]3)[C@:16]3([CH3:17])[C@H:11]([CH2:12][C:13](=[O:24])[CH2:14][CH2:15]3)[CH2:10][CH2:9]4)[CH2:6][CH2:5]2)=[O:35])[CH2:28][CH2:27]1

참가 물질

4

반응물 2

HCID 8673347421-Bromo-5alpha-pregnane-3,11,20-trioneHCID 178526202HCID 178526202, 화합물

생성물 1

HCID 8673347521-Morpholinoacetylthio-5alpha-pregnane-3,11,20-trione

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

21-Bromo-5α-pregnane-3,11,20-trione (1.04 g.) was refluxed in dry acetone (100 ml) with morpholino thioacetic acid (600 mg) for 15 minutes. The reaction mixture was concentrated, partitioned between ethyl acetate, water, pH 8, the organic layer was washed, dried (MgSO4) and evaporated to an off white solid (1.26g.)

후처리

  1. concentrationThe reaction mixture was concentrated
  2. custompartitioned between ethyl acetate, water, pH 8
  3. washthe organic layer was washed
  4. dry with materialdried (MgSO4)
  5. customevaporated to an off white solid (1.26g.)

출처 및 근거

ORD 기록
ord-01fbc72acd6a4967b3bcd2a3737a6870
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03959260

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