홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Diethyl ether 2-propanol → 2-Pyrrolidino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester

HRID 1077031
노트
인쇄 미리보기

반응식

HRID 1077031 반응식
COC(=O)C[C:5]([CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=1)=[O:6].[CH2:19]([O:21][C:22](=[O:31])[CH:23]=[C:24]([N:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1)[NH2:25])[CH3:20].[CH:32]([OH:35])(C)C.[CH3:36][CH2:37]OCC>C(O)C>[CH3:32][O:35][C:5]([CH:7]1[C:36]([CH3:37])=[N:25][C:24]([N:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)=[C:23]([C:22]([O:21][CH2:19][CH3:20])=[O:31])[CH:8]1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=1)=[O:6]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 22147583Diethyl ether 2-propanolHCID 534430103-Nitrobenzylideneacetoacetic acid methyl esterHCID 706080083-Pyrrolidino-3-aminoacrylic acid ethyl ester

생성물 1

HCID 706082142-Pyrrolidino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester수율 74%

시약·촉매·용매 1

HCID 702
Ethanol
용매

실험 절차

Boiling a solution of 12.5 g of 3-nitrobenzylideneacetoacetic acid methyl ester and 9.2 g of 3-pyrrolidino-3-aminoacrylic acid ethyl ester in 100 ml of ethanol for 2 hours yields 2-pyrrolidino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester of melting point 103°C (isopropanol/ether). Yield: 74% of theory.

후처리

  1. customfor 2 hours

출처 및 근거

ORD 기록
ord-b5d66469bb5444a197e54f4c5d27921c
출처 데이터셋
uspto-grants-1976_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US03959292

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트