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Ethanol → 2-Dimethylamino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester

HRID 1077033
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인쇄 미리보기

반응식

HRID 1077033 반응식
COC(=O)C[C:5]([CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=1)=[O:6].[CH2:19]([O:21][C:22](=[O:29])[CH:23]=[C:24]([NH2:28])[N:25]([CH3:27])[CH3:26])[CH3:20].[CH:30]([OH:33])(C)C.[CH2:34](O)[CH3:35]>>[CH3:30][O:33][C:5]([CH:7]1[C:34]([CH3:35])=[N:28][C:24]([N:25]([CH3:27])[CH3:26])=[C:23]([C:22]([O:21][CH2:19][CH3:20])=[O:29])[CH:8]1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=1)=[O:6]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 4

HCID 702EthanolHCID 3776IsopropanolHCID 534430103-Nitrobenzylideneacetoacetic acid methyl esterHCID 867334643-Amino-3-dimethylaminoacrylic acid ethyl ester

생성물 1

HCID 706080742-Dimethylamino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester수율 54%

실험 절차

Boiling a solution of 12.5 g of 3-nitrobenzylideneacetoacetic acid methyl ester and 8.2 g of 3-amino-3-dimethylaminoacrylic acid ethyl ester in 100 ml of ethanol for 2 hours yields 2-dimethylamino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester-5-methyl ester of melting point 95°C (isopropanol). Yield: 54% of theory.

후처리

  1. customfor 2 hours

출처 및 근거

ORD 기록
ord-25e3e7f26bdf4ae3bc4fc45fd42922f5
출처 데이터셋
uspto-grants-1976_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US03959292

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