tert-Butyl ethyl ethanedioate → HCID 21535782, 화합물

HRID 1077053노트

반응식

HRID 1077053 반응식
[Li][C:2]#[C:3][CH:4]([CH3:6])[CH3:5].[C:7](OCC)(=[O:15])[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9]>C1COCC1>[CH3:5][CH:4]([CH3:6])[C:3]#[C:2][C:7](=[O:15])[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9]

참가 물질

4

반응물 2

HCID 14648212tert-Butyl ethyl ethanedioateHCID 178506794HCID 178506794, 화합물2회

생성물 1

HCID 21535782HCID 21535782, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

reacting 1-lithio-3-methylbut-1-yne with a 150% to 165% excess of the stoichiometric amount of ethyl t-butyl oxalate in THF containing an amount of a suitable hydrocarbon solvent sufficient to solubilize said 1-lithio-3-methylbut-1-yne, the reaction being carried out under anhydrous conditions in an inert atmosphere at a temperature of from 0° to 10° to form t-butyl 5-methyl-2-oxohex-3-ynoate;

후처리

  1. custombeing carried out under anhydrous conditions in an inert atmosphere at a temperature of from 0° to 10°

출처 및 근거

ORD 기록
ord-918ae0e292d846618cd235d7a51b64e5
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03959312

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