Sulfuric Acid → 1-Diethylamino-6-(m-methoxyphenyl)heptan-3-one

HRID 1077132노트

반응식

HRID 1077132 반응식
[CH2:1]([N:3]([CH2:19][CH3:20])[CH2:4][C:5]#[C:6][CH2:7][CH2:8][CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=1)[CH3:10])[CH3:2].S(=O)(=O)(O)[OH:22]>>[CH2:19]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][C:6](=[O:22])[CH2:7][CH2:8][CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=1)[CH3:10])[CH3:20]

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 214856761-Diethylamino-6-(m-methoxyphenyl)hept-2-yne

생성물 1

HCID 214857581-Diethylamino-6-(m-methoxyphenyl)heptan-3-one

실험 절차

Dissolve 1-diethylamino-6-(m-methoxyphenyl)hept-2-yne (13.6 g) in 10% aqueous sulphuric acid (40 cc) and stir with mercuric sulphate (0.69 g) for 2 hours at 70°. Filter the cooled solution, make basic with 10% aqueous sodium hydroxide and extract with ether. Wash the ethereal solution with water and brine, and dry (Na2SO4). Evaporate the solvent and distil the residue to obtain 1-diethylamino-6-(m-methoxyphenyl)heptan-3-one which has partially eliminated to 6-(m-methoxyphenyl)hept-1-en-3-one during the distillation, b.p. 145°/12 mm Hg.

후처리

  1. filtrationFilter the cooled solution
  2. extractionextract with ether
  3. washWash the ethereal solution with water and brine
  4. dry with materialdry (Na2SO4)
  5. customEvaporate the solvent
  6. customdistil the residue

출처 및 근거

ORD 기록
ord-a67a1a592125445e9d9bb445aa356d33
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03959322

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