Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → (17Beta)-13-Ethyl-3-methoxygona-2,5(10)-dien-17-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | (17beta)-13-Ethyl-3-methoxygona-1,3,5(10)-trien-17-ol | HCID 66432 | — |
| 반응물 | Lithium | HCID 3028194 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1-Methoxy-2-propanol | HCID 7900 | — |
| 생성물 | (17Beta)-13-Ethyl-3-methoxygona-2,5(10)-dien-17-ol | HCID 101950 | — |
반응 단계
To 13β-ethyl-3-methoxy-gona-1,3,5(10)-trien-17β-ol (1.0 g.) in 1-methoxypropan-2-ol (100 cc.) add liquid ammonia (200 cc.), followed by lithium metal (1.2 g.) in small pieces with stirring. After discharge of the blue color add an excess ammonium chloride, followed by water; filter off the crude 13β-ethyl-3-methoxy-gona-2,5(10)-dien-17β-ol and dry, m.p. 98°-104°. No selective ultra-violet absorption beyond 220 mμ; infrared absorption peaks at 3.03, 5.92, 6.01 μ.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03959322 |
| 출처 데이터셋 | uspto-grants-1976_05 |
| ORD ID | ord-e3143b7af7464c89a6c753fe74b87862 |
| 출처 메모 | uspto-grants-1976_05 |