Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 17beta-Allyloxy-13-ethyl-3-methoxygona-1,3,5(10)-triene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Allyl bromide | HCID 7841 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | (17beta)-13-Ethyl-3-methoxygona-1,3,5(10)-trien-17-ol | HCID 66432 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 17beta-Allyloxy-13-ethyl-3-methoxygona-1,3,5(10)-triene | HCID 86733492 | — |
반응 단계
Reflux a suspension of 5.0 g. of dl-13-ethyl-3-methoxygona-1,3,5(10)-triene-17β-ol, 100 mg. of xylene, and 3.9 g. of sodium hydride (50% in mineral oil) for 1.5 hours. Add 14.5 ml. of allyl bromide and reflux for 22 hours. Make the reaction mixture acidic with dilute hydrochloric acid and extract the organic layer with sodium bicarbonate solution. Chromatograph the residue on alumina (Grade I neutral) in hexane and eluate the product with ether to obtain dl-17β-allyloxy-13-ethyl-3-methoxygona-1,3,5(10)-triene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03959322 |
| 출처 데이터셋 | uspto-grants-1976_05 |
| ORD ID | ord-db1a331c08994f5382dc45e5bb1d0a9b |
| 출처 메모 | uspto-grants-1976_05 |