Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 13-Ethyl-17beta-(2-dimethylaminoethoxy)-3-methoxygona-1,3,5(10)-triene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium amide | HCID 24533 | — |
| 반응물 | (17beta)-13-Ethyl-3-methoxygona-1,3,5(10)-trien-17-ol | HCID 66432 | — |
| 반응물 | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 13-Ethyl-17beta-(2-dimethylaminoethoxy)-3-methoxygona-1,3,5(10)-triene | HCID 68143163 | — |
반응 단계
Stir a solution of 860 mg. of sodium amide in 15 ml. of benzene and add 3.0 g. of dl-13-ethyl-3-methoxygona-1,3,5(10)-trien-17β-ol in 15 ml. of benzene. Heat for 2 hours at 70°-83°. Cool to room temperature and add 1.58 g. of N,N-dimethylamino-2-chloroethane hydrochloride and reflux for 16 hours. Pour over ice and acidify reaction mixture with 2 N hydrochloric acid. Extract with ether and basify the aqueous layer with 15% sodium hydroxide. Isolate material with ether. Evaporate the ether to obtain dl-13-ethyl-17β-(2-dimethylaminoethoxy)-3-methoxygona-1,3,5(10)-triene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03959322 |
| 출처 데이터셋 | uspto-grants-1976_05 |
| ORD ID | ord-804e56982a2a4808889991d28281b950 |
| 출처 메모 | uspto-grants-1976_05 |