7-Dehydrocholesterol → Previtamin D3

HRID 1077380

반응식

HRID 1077380 반응식
[CH3:1][C@@H:2]([C@@H:9]1[C@@:13]2([CH3:28])[CH2:14][CH2:15][C@@H:16]3[C@@:21]4([CH3:27])[CH2:22][CH2:23][C@H:24]([OH:26])[CH2:25][C:20]4=[CH:19][CH:18]=[C:17]3[C@@H:12]2[CH2:11][CH2:10]1)[CH2:3][CH2:4][CH2:5][CH:6]([CH3:8])[CH3:7]>CCCCCC>[CH3:27][C:21]1[CH2:22][CH2:23][C@H:24]([OH:26])[CH2:25][C:20]=1/[CH:19]=[CH:18]\[C:17]1[C@@H:12]2[CH2:11][CH2:10][C@H:9]([C@@H:2]([CH2:3][CH2:4][CH2:5][CH:6]([CH3:8])[CH3:7])[CH3:1])[C@@:13]2([CH3:28])[CH2:14][CH2:15][CH:16]=1

참가 물질

3

반응물 1

HCID 4394237-Dehydrocholesterol

생성물 1

HCID 5281058Previtamin D3

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

From the hexane data, it was concluded that the material eluted at 12.2 min is tachysterol. The size and kind of microreactor is important to the ratio of products formed. Where the microreactor is several times the size of the 7-DHC, the undesirable side reactions are more favored. For example the silica with 60 Å pores (Ex. 10 and 11) give a ratio of previtamin D3 :tachysterol similar to that of the reaction in hexane (Ex. 9). In micelles (Ex. 16), however, which form a similarly sized microreactor, but with an environment similar to that of a hydrocarbon solvent, tachysterol is very heavily favored.

후처리

  1. washeluted at 12.2 min
  2. customformed

출처 및 근거

ORD 기록
ord-f6bb1851d396499fbfe04619d81b2ea2
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05543016

연결된 노트

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