Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylcarbodiimide → 2-(Pyrrolidin-1-yl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 4-Cyclopentene-1,3-diol, 1-acetate, (1R,3S)-rel- | HCID 9855498 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(Pyrrolidin-1-yl)pyridine | HCID 11019020 | — |
반응 단계
3.1 mmol of the cyclopentenol, 3.1 mmol of DCC and 0.1 mmol of PP are dissolved in CH2Cl2 in a 100 ml flask fitted with a CaCl2 tube, 3.1 mmol of the carboxylic acid are added at 0°-5° C. with ice cooling, and the mixture is stirred at room temperature for 24 hours. The precipitated urea is filtered off, the solvent is removed by evaporation, and the crude product is recrystallized a number of times from ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05543076 |
| 출처 데이터셋 | uspto-grants-1996_08 |
| ORD ID | ord-6af82f90d71247dcb7e0ca8bd70bc64b |
| 출처 메모 | uspto-grants-1996_08 |