3-(2,3-Dihydro-1,4-benzodioxin-6-yl)acrylic acid → 1H-Purine-2,6-dione, 3,7-dihydro-8-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethenyl)-1,3-dipropyl-, (E)-

HRID 1077451

반응식

HRID 1077451 반응식
[NH2:1][C:2]1[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=1[NH2:8].[O:17]1[C:22]2[CH:23]=[CH:24][C:25]([CH:27]=[CH:28][C:29](O)=O)=[CH:26][C:21]=2[O:20][CH2:19][CH2:18]1>>[O:17]1[C:22]2[CH:23]=[CH:24][C:25](/[CH:27]=[CH:28]/[C:29]3[NH:1][C:2]4[C:3](=[O:16])[N:4]([CH2:13][CH2:14][CH3:15])[C:5](=[O:12])[N:6]([CH2:9][CH2:10][CH3:11])[C:7]=4[N:8]=3)=[CH:26][C:21]=2[O:20][CH2:19][CH2:18]1

참가 물질

3

반응물 2

HCID 46440313-(2,3-Dihydro-1,4-benzodioxin-6-yl)acrylic acidHCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione

생성물 1

HCID 64488081H-Purine-2,6-dione, 3,7-dihydro-8-(2-(2,3-dihydro-1,4-benzodioxin-6-yl)ethenyl)-1,3-dipropyl-, (E)-수율 65.2%

실험 절차

Substantially the same procedure as in Reference Example 1 was repeated using 1.35 g (5.96 mmol) of 5,6-diamino-1,3-dipropyluracil and 1.35 g (6.55 mmol) of 3-(1,4-benzodioxan-6-yl)acrylic acid. Then, the resultant crude crystals were recrystallized from ethanol/water to give 1.54 g (yield 65%) of Compound 17 as white needles.

후처리

  1. customThen, the resultant crude crystals were recrystallized from ethanol/water

출처 및 근거

ORD 기록
ord-a7b835e417ba46cfbf9a560b265f5316
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05543415

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