3-(3,4-Difluorophenyl)prop-2-enoic acid → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3,4-difluorophenyl)ethenyl)-, (E)-

HRID 1077497노트

반응식

HRID 1077497 반응식
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[F:15][C:16]1[CH:17]=[C:18]([CH:24]=[CH:25][C:26]=1[F:27])[CH:19]=[CH:20][C:21](O)=O>>[F:15][C:16]1[CH:17]=[C:18]([CH:24]=[CH:25][C:26]=1[F:27])/[CH:19]=[CH:20]/[C:21]1[NH:1][C:2]2[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=2[N:8]=1

참가 물질

3

반응물 2

HCID 1454863-(3,4-Difluorophenyl)prop-2-enoic acidHCID 45721335,6-Diamino-1,3-diethyluracil

생성물 1

HCID 64488921H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3,4-difluorophenyl)ethenyl)-, (E)-수율 49%

실험 절차

Substantially the same procedure as in Reference Example 70 was repeated using 2.50 g (12.6 mmol) of 5,6-diamino-1,3-diethyluracil and 2.79 g (15.2 mmol) of 3,4-difluorocinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 2.12 g (yield 49%) of Compound 111 as gray plates.

후처리

  1. customThen, the resultant crude crystals were recrystallized from dioxane/water

출처 및 근거

ORD 기록
ord-3d292e33de5245f5b136fe6152a0945e
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05543415

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