3-(3-Fluorophenyl)-2-propenoic acid → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3-fluorophenyl)ethenyl)-, (E)-

HRID 1077504

반응식

HRID 1077504 반응식
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[F:15][C:16]1[CH:17]=[C:18]([CH:24]=[CH:25][CH:26]=1)[CH:19]=[CH:20][C:21](O)=O>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:21](/[CH:20]=[CH:19]/[C:18]3[CH:24]=[CH:25][CH:26]=[C:16]([F:15])[CH:17]=3)=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

참가 물질

3

반응물 2

HCID 886063-(3-Fluorophenyl)-2-propenoic acidHCID 45721335,6-Diamino-1,3-diethyluracil

생성물 1

HCID 64489041H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3-fluorophenyl)ethenyl)-, (E)-수율 40%

실험 절차

Substantially the same procedure as in Reference Example 70 was repeated using 3.00 g (15.1 mmol) of 5,6-diamino-1,3-diethyluracil and 2.77 g (16.7 retool) of 3-fluorocinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 1.96 g (yield 40% of Compound 127 as a pale yellow powder.

후처리

  1. customThen, the resultant crude crystals were recrystallized from dioxane/water

출처 및 근거

ORD 기록
ord-0d2af49e01bd48ab81f81d6f0376024d
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05543415

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