Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Dimethylamino)-1-(2-thienyl)-2-propen-1-one → 4-(2-Thienyl)-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Dimethylamino)-1-(2-thienyl)-2-propen-1-one | HCID 602399 | — |
| 반응물 | 3-(1,1,2,2-Tetrafluoroethoxy)phenylguanidine nitrate | HCID 178512518 | — |
| 생성물 | 4-(2-Thienyl)-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine | HCID 10595267 | — |
반응 단계
In accordance with the eneral procedure described in Example 1, reaction of 100 mg (0.55 mmol) of 3-dimethylamino-1-(2-thienyl)-2-propen-1-one [described in EP-A-0 233 461] and 173 mg (0.55 mmol) of 3-(1,1,2,2-tetrafluoroethoxy)phenylguanidine nitrate gives N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-4-(2-thienyl)-2-pyrimidine-amine; FAB-MS:370 (M+ +1), m.p. 115°-116°, Rf =0.95 (ethyl acetate).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05543520 |
| 출처 데이터셋 | uspto-grants-1996_08 |
| ORD ID | ord-68c75e54af604fb0b87ad9b050112635 |
| 출처 메모 | uspto-grants-1996_08 |