2-Nitroimidazole → (S)-(+)-alpha-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

반응식

[N+:1]([C:4]1[NH:5][CH:6]=[CH:7][N:8]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[CH2:15]([C@H:17]1[O:19][CH2:18]1)[Cl:16]>>[Cl:16][CH2:15][C@@H:17]([OH:19])[CH2:18][N:5]1[CH:6]=[CH:7][N:8]=[C:4]1[N+:1]([O-:3])=[O:2]

참가 물질

반응물 3

HCID 107012-Nitroimidazole

HCID 11430Potassium Carbonate

HCID 149428(+)-Epichlorohydrin

생성물 1

HCID 11052772(S)-(+)-alpha-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

실험 절차

Alternatively, reaction of 2-nitroimidazole, anhydrous potassium carbonate, and (S)-(+)-epichlorohydrin as described in Example 1(a) gives the product.

후처리

customgives the product

출처 및 근거

ORD 기록: ord-81b62794665148c99936c9a9a62a5c6d
출처 데이터셋: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05543527

반응 노트

불러오는 중…