Methanol → HCID 19793837, 화합물

반응식

[F:1][C:2]([F:10])=[CH:3][CH2:4][CH2:5][CH2:6][C:7](Cl)=[O:8].N1C=CC=CC=1.[CH3:17][OH:18]>>[CH3:17][O:18][C:7](=[O:8])[CH2:6][CH2:5][CH2:4][CH:3]=[C:2]([F:10])[F:1]

참가 물질

반응물 3

HCID 887Methanol

HCID 1049Pyridine

HCID 197938396,6-Difluorohex-5-enoic acid chloride

생성물 1

HCID 19793837HCID 19793837, 화합물

실험 절차

42.1 g of 6,6-difluorohex-5-enoic acid chloride are added slowly at 10° to 17.6 g of pyridine in 200 ml of methanol. The mixture is then stirred at room temperature for 5 hours. The excess methanol is evaporated off in a rotary evaporator and the residue is taken up in tert-butyl methyl ether and washed with water. The organic phase is dried over sodium sulfate and concentrated to dryness by evaporation. The residue is distilled at 60 mbar. The title compound is obtained in the form of a colourless oil.