참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl 2-methylacetoacetate | HCID 701 | — |
| 반응물 | 4-Toluamidine | HCID 122754 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one | HCID 135704739 | 85.4% |
반응 단계
To a solution of 4-methylbenzamidine (4.4 g) in 30 ml of ethanol was added ethyl 2-methylacetoacetate (6.1 g), and the mixture refluxed for 4 hours, giving a precipitate. The mixture was cooled to 0° C., the solid filtered off, washed with ethanol, and dried under reduced pressure, yielding 6 g of 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one, m.p. 250° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05545645 |
|---|
| 출처 데이터셋 | uspto-grants-1996_08 |
|---|
| ORD ID | ord-409d113b6f914bff874dfd871b70319e |
|---|
| 출처 메모 | uspto-grants-1996_08 |
|---|
