1-Benzyl-4-(1-indolyl)-piperidine → 1-(Piperidin-4-yl)-1H-indole

HRID 1077933노트

반응식

HRID 1077933 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].C(O)(=O)C>[N:14]1([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15]1

참가 물질

4

반응물 1

HCID 212222251-Benzyl-4-(1-indolyl)-piperidine

생성물 1

HCID 140907551-(Piperidin-4-yl)-1H-indole수율 80%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 176Acetic Acid용매

반응 조건

온도
80 °C

실험 절차

A glacial acetic acid (15 mL) solution containing Pd(OH)2 /C and 1-benzyl-4-(1-indolyl)-piperidine was placed under an H2 atmosphere. The reaction temperature was raised to 80° C. After 1 hour, the reaction was cooled to room temperature and filtered. The filtrate was made basic (pH 8-9) with saturated NaHCO3, and extracted with methylene chloride. The extract was washed with water, dried, and concentrated. This material was sufficiently pure for further reactions giving 1.09 g (80% yield) of the title compound.

후처리

  1. temperaturethe reaction was cooled to room temperature
  2. filtrationfiltered
  3. extractionextracted with methylene chloride
  4. washThe extract was washed with water
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3ca1a08877b24b339fa209fc065331b5
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05545636

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