Pyridine → HCID 54390883, 화합물

HRID 1078031노트

반응식

HRID 1078031 반응식
[F:1][C@H:2]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH2:3][OH:4].N1C=CC=CC=1.[S:17](Cl)([C:20]1[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=1)(=[O:19])=[O:18]>O>[S:17]([C:20]1[CH:26]=[CH:25][C:23]([CH3:24])=[CH:22][CH:21]=1)([O:4][CH2:3][C@H:2]([F:1])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])(=[O:19])=[O:18]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 10855629(R)-(+)-2-fluorooctanol

생성물 1

HCID 54390883HCID 54390883, 화합물수율 93.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A reaction vessel was charged with 10.0 g of (2R)-2fluorooctanol and 25 ml of pyridine, and 13.0 g of tosyl chloride was added with stirring at 0°-5° C. After the reaction was effected for 6 hours, the mixture was poured into water and extracted with 100 ml of benzene. The resultant solution in benzene was washed sequentially with water, an aqueous solution of NaHCO3 and water in that order, and dried over Glauber's salt. The solvent was distilled off to obtain 19.0 g (yield 92.6%) of crude (2R)-2-fluorooctyl tosylate as the residue.

후처리

  1. additionwas added
  2. extractionextracted with 100 ml of benzene
  3. washThe resultant solution in benzene was washed sequentially with water
  4. dry with materialan aqueous solution of NaHCO3 and water in that order, and dried over Glauber's salt
  5. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-7092816a216d428eb96c78ed3903ba42
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05545747

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