1,2-Dichloro-4-nitrobenzene → 2-Chloro-1-fluoro-4-nitrobenzene

HRID 1078054

반응식

HRID 1078054 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1Cl.[F-:12].[K+]>[Cl-].C([N+](CCCCCCCCCCCCCCCCCC)(C)C)CCCCCCCCCCCCCCCCC>[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[F:12]

참가 물질

4

반응물 2

HCID 74431,2-Dichloro-4-nitrobenzeneHCID 522689Potassium Fluoride

생성물 1

HCID 676882-Chloro-1-fluoro-4-nitrobenzene수율 69%

시약·촉매·용매 1

HCID 7879Distearyldimethylammonium chloride촉매

실험 절차

576 g (3 mol) of 3,4-dichloronitrobenzene, 58 g (0.1 mol) of distearyldimethylammonium chloride and 139 g (2.4 mol) of potassium fluoride were reacted analogously to Example 1. After filtering with suction, the residue was dissolved in water, the organic phase was separated off and the combined organic phases were fractionated. 289 g (69%, relative to potassium fluoride employed) of 3-chloro-4-fluoronitrobenzene were obtained.

후처리

  1. filtrationAfter filtering with suction
  2. dissolutionthe residue was dissolved in water
  3. customthe organic phase was separated off

출처 및 근거

ORD 기록
ord-e30add03b270414caea64b94a829809e
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05545768

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