Potassium Carbonate → 2-Amino-3-cyano-4-methyl-5-ethynylpyridine

HRID 1078242노트

반응식

HRID 1078242 반응식
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH3:10])[C:5]([C:11]#[C:12][Si](C)(C)C)=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH3:10])[C:5]([C:11]#[CH:12])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 197071982-Amino-3-cyano-4-methyl-5-(trimethylsilylethynyl)pyridine

생성물 1

HCID 233567022-Amino-3-cyano-4-methyl-5-ethynylpyridine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2.8 grams (0.012 mole) of 2-amino-3-cyano-4-methyl-5-(trimethylsilylethynyl)pyridine and 1.8 grams (0.012 mole) of potassium carbonate in 100 mL of methanol is stirred at ambient temperature for one hour. The reaction mixture is then concentrated under reduced pressure to a residue. The residue is taken up in about 150 mL of water, and the solution is extracted with two 250 mL portions of diethyl ether. The combined extracts are dried with magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure, yielding 2-amino-3-cyano-4-methyl-5-ethynylpyridine.

후처리

  1. concentrationThe reaction mixture is then concentrated under reduced pressure to a residue
  2. extractionthe solution is extracted with two 250 mL portions of diethyl ether
  3. dry with materialThe combined extracts are dried with magnesium sulfate
  4. filtrationfiltered
  5. concentrationThe filtrate is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-47c5237d19ec4855aa10deed945195a6
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05547954

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