Imidazole → N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propionamide

HRID 1078394노트

반응식

HRID 1078394 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:11][C:12](=[O:15])[CH:13]=[CH2:14])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[NH:16]1[CH:20]=[CH:19][N:18]=[CH:17]1>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([NH:11][C:12](=[O:15])[CH2:13][CH2:14][N:16]2[CH:20]=[CH:19][N:18]=[CH:17]2)([CH3:10])[CH3:9])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 18349731N-[1-(4-chlorophenyl)-1-methylethyl]-acrylamide

생성물 1

HCID 19429499N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propionamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of N-[1-(4-chlorophenyl)-1-methylethyl]acrylamide (200 g), imidazole (60.9 g), Triton B (20 ml) and 1,4-dioxane (1600 ml) was stirred and boiled under reflux for 20 hours. The solvent was removed under reduced pressure and the residue dissolved in dichloromethane (2000 ml). The mixture was extracted with 2M hydrochloric acid. The combined aqueous extracts were basified with 2M sodium hydroxide solution and extracted with dichloromethane to give N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propionamide, m.p. 154°-155° C.

후처리

  1. temperatureunder reflux for 20 hours
  2. customThe solvent was removed under reduced pressure
  3. dissolutionthe residue dissolved in dichloromethane (2000 ml)
  4. extractionThe mixture was extracted with 2M hydrochloric acid
  5. extractionextracted with dichloromethane

출처 및 근거

ORD 기록
ord-0aabdcbbc38d466f976218d0fad2104f
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05547972

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