Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-BUTYL CHLORIDE → (2E)-2-[2-(4-tert-butylphenoxy)phenyl]-2-methoxyimino-N-methylacetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-BUTYL CHLORIDE | HCID 10486 | — |
| 반응물 | (2E)-2-methoxyimino-N-methyl-2-(2-phenoxyphenyl)acetamide | HCID 5483872 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Nitromethane | HCID 6375 | — |
| 생성물 | (2E)-2-[2-(4-tert-butylphenoxy)phenyl]-2-methoxyimino-N-methylacetamide | HCID 76327444 | 104.4% |
반응 단계
To a solution of (E)-N-methyl-2-(2-phenoxyphenyl)2-methoxyiminoacetamide (300 mg) in nitromethane (3 ml), aluminium chloride (423 mg) and t-butyl chloride (147 mg) were added, followed by stirring at room temperature for 1 hour. The reaction mixture was diluted with water and extracted with diethyl ether. The solvent was dried and evaporated, and the residue was purified by silica gel column chromatography with a mixture of hexane and ethyl acetate to give 375 mg of the objective compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05548078 |
| 출처 데이터셋 | uspto-grants-1996_08 |
| ORD ID | ord-d9f7ce61bbf54e8087207362cccb1314 |
| 출처 메모 | uspto-grants-1996_08 |