Acetic Acid → N-[4-(2-Bromoacetyl)Phenyl]Acetamide

HRID 10786

반응식

HRID 10786 반응식
[Br:1]Br.[C:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])=[CH:8][CH:7]=1)(=[O:5])[CH3:4].C(O)(=O)C>C(Cl)(Cl)(Cl)Cl>[Br:1][CH2:4][C:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])=[CH:8][CH:7]=1)=[O:5]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 24408BromineHCID 75937N-(p-acetylphenyl)acetamide

생성물 1

HCID 12364739N-[4-(2-Bromoacetyl)Phenyl]Acetamide수율 97.6%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매2회

실험 절차

A solution of bromine (0.31 mL, 5.9 mmol) in carbon tetrachloride (10 mL) was added to a suspension of N-(4-acetylphenyl)acetamide (1 g, 5.6 mmol) (Lancaster Synthesis) in carbon tetrachloride (20 mL). The reaction mixture was stirred for several hours but TLC indicated only starting material. Acetic acid (10 mL) was added, and the reaction mixture was stirred overnight. Filtration gave N-[4-(bromoacetyl)phenyl]acetamide (1.4 g) as a solid. HPLC indicated that the purity was approximately 80%. This material was used directly in subsequent steps without purification.

후처리

  1. stirringthe reaction mixture was stirred overnight
  2. filtrationFiltration

출처 및 근거

ORD 기록
ord-f5d11cfe3cd8412daee3285f06654237
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094896B2

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