Bromine → 3-Fluoro-4-methoxyphenacyl bromide

HRID 10788

반응식

HRID 10788 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:10](=[O:12])[CH3:11])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[Br:13]Br>O1CCOCC1>[Br:13][CH2:11][C:10]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=1)=[O:12]

참가 물질

4

반응물 2

HCID 24408BromineHCID 968281-(3-Fluoro-4-methoxyphenyl)ethan-1-one

생성물 1

HCID 70618463-Fluoro-4-methoxyphenacyl bromide수율 63%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a solution of 3′-fluoro-4′-methoxyacetophenone (1 g, 5.9 mmol) (Aldrich) in dioxane (10 mL) was added dropwise a solution of bromine (1.13 g, 7.1 mmol) in dioxane (30 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:4 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3-fluoro-4-methoxyphenyl)ethanone as a white powder (910 mg, 63% yield).

후처리

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue was purified by flash chromatography, with 10:4 hexanes/dichloromethane as an eluant

출처 및 근거

ORD 기록
ord-a2a922a5821941fc85660d7e312d45ad
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094896B2

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