Bromine → 2-Bromo-1-(3,5-difluorophenyl)ethanone

HRID 10789

반응식

HRID 10789 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[C:6]([F:8])[CH:7]=1.[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=1)=[O:11]

참가 물질

4

반응물 2

HCID 24408BromineHCID 5185963',5'-Difluoroacetophenone

생성물 1

HCID 27783312-Bromo-1-(3,5-difluorophenyl)ethanone수율 64.3%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a solution of 3′,5′-difluoroacetophenone (3 g, 19.2 mmol) (Lancaster Synthesis) in dioxane (30 mL) was added dropwise a solution of bromine (3.67 g, 23 mmol) in dioxane (75 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3,5-difluorophenyl)ethanone as a colorless oil (2.9 g, 64% yield).

후처리

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant

출처 및 근거

ORD 기록
ord-b766bbeecace419eaa52b615ff7cd9e8
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094896B2

연결된 노트

불러오는 중…