Bromine → 2-Bromo-1-(3,5-difluorophenyl)ethanone

To a solution of 3′,5′-difluoroacetophenone (3 g, 19.2 mmol) (Lancaster Synthesis) in dioxane (30 mL) was added dropwise a solution of bromine (3.67 g, 23 mmol) in dioxane (75 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3,5-difluorophenyl)ethanone as a colorless oil (2.9 g, 64% yield).

1. concentrationthe mixture was concentrated in vacuo
2. customthe residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant

ORD 기록

ord-b766bbeecace419eaa52b615ff7cd9e8

출처 데이터셋

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07094896B2