N-Benzylglycine ethyl ester → Ethyl 1-benzyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate

반응식

Cl[C:2]1[CH2:6][CH2:5][CH2:4][C:3]=1[CH:7]=O.[CH2:9]([O:11][C:12](=[O:22])[CH2:13][NH:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH3:10]>>[CH2:15]([N:14]1[C:13]([C:12]([O:11][CH2:9][CH3:10])=[O:22])=[CH:7][C:3]2[CH2:4][CH2:5][CH2:6][C:2]1=2)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

반응물 2

HCID 80908N-Benzylglycine ethyl ester

HCID 123899702-Chlorocyclopent-1-ene-1-carbaldehyde

생성물 1

HCID 13592288Ethyl 1-benzyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole-2-carboxylate

반응 조건

온도: 110 °C

실험 절차

25 g (0.191 mol) of 2-chloro-1-formylcyclopent-1-ene are added to 73.9 g (0.382 mol) of N-benzylglycine ethyl ester at room temperature and the mixture is then heated to 110° C. Working-up is carried out as indicated in Example 1.

출처 및 근거

ORD 기록: ord-c2b7688883e34af89553bb1e74e8a561
출처 데이터셋: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05550255

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