5-Aminoindole → 7-Fluoro-4-(5-indolylamino)quinazoline hydrochloride

HRID 1079358노트

반응식

HRID 1079358 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][CH:18]=[CH:17]2>>[ClH:1].[F:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:13][C:14]3[CH:15]=[C:16]4[C:20](=[CH:21][CH:22]=3)[NH:19][CH:18]=[CH:17]4)=[N:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

참가 물질

3

반응물 2

HCID 788675-AminoindoleHCID 162270134-Chloro-7-fluoroquinazoline

생성물 1

HCID 233667397-Fluoro-4-(5-indolylamino)quinazoline hydrochloride수율 65%

실험 절차

Using an analogous procedure to that described in Example 5, 4-chloro-7-fluoroquinazoline was reacted with 5-aminoindole to give 7-fluoro-4-(5-indolylamino)quinazoline hydrochloride in 65% yield;

출처 및 근거

ORD 기록
ord-3594bba023da4897b8c9f50543b50836
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05580870

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