Piperidine → Piperidine, 1-(4-nitrophenyl)-

HRID 1079392

반응식

HRID 1079392 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>CN(C)C=O>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:3][CH:4]=1)([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 9590p-Fluoronitrobenzene

생성물 1

HCID 81049Piperidine, 1-(4-nitrophenyl)-

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of p-fluoronitrobenzene (31.8 ml) in dimethylformamide (200 ml) was ice-cooled and to this was added piperidine (60 ml) dropwise, followed by stirring with ice cooling for 2 hours. After the solvent was distilled off, the residual oily product was dissolved in ethyl acetate ester (200 ml), followed by washing in turn with aqueous saturated solution of sodium bicarbonate and water. Then, the solution was dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was recrystallized from n-hexane to obtain N-(4-nitrophenyl)piperidine as yellow crystals (52.8 g).

후처리

  1. temperaturecooled
  2. distillationAfter the solvent was distilled off
  3. dissolutionthe residual oily product was dissolved in ethyl acetate ester (200 ml)
  4. washby washing in turn with aqueous saturated solution of sodium bicarbonate and water
  5. dry with materialThen, the solution was dried over anhydrous magnesium sulfate
  6. distillationAfter the solvent was distilled off
  7. customthe residue was recrystallized from n-hexane

출처 및 근거

ORD 기록
ord-2cf7a327371f4730a5c5bfa29490dc36
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05580883

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