Acetyl chloride → N-(4-(1-Piperidinyl)phenyl)acetamide

HRID 1079394노트

반응식

HRID 1079394 반응식
Cl.Cl.[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1.C(N(CC)CC)C.[C:23](Cl)(=[O:25])[CH3:24]>O>[C:23]([NH:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1)(=[O:25])[CH3:24]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 233669404-(Piperidin-1-yl)aniline dihydrochloride

생성물 1

HCID 732499N-(4-(1-Piperidinyl)phenyl)acetamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of N-(4-aminophenyl)piperidine dihydrochloride (2.49 g) and triethylamine (5.6 g) in dichloroform (30 ml) was ice-cooled and to this was added dropwise acetyl chloride (1.42 ml). After stirred at room temperature for 30 minutes, water (10 ml) was added to the mixture and the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off and then the residue was recrystallized from ethyl ether to obtain N(4-acetylaminophenyl)piperidine (2 g) as colorless crystals, m.p. 150°-152° C.

후처리

  1. temperaturecooled
  2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  3. distillationThe solvent was distilled off
  4. customthe residue was recrystallized from ethyl ether

출처 및 근거

ORD 기록
ord-45b0e8bf45724a65aa6aa2fdba130a55
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05580883

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