Ammonia → 2-[-(alpha-Amino-Nalpha-(benzylcarbonyl)glycinyl)amino]-benzophenone

HRID 1080378노트

반응식

HRID 1080378 반응식
C(S[CH:5]([C:17]([NH:19][C:20]1[CH:33]=[CH:32][CH:31]=[CH:30][C:21]=1[C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:23])=[O:18])[NH:6][C:7]([O:9]CC1C=CC=CC=1)=O)(C)C.[NH3:34]>>[NH2:34][CH:5]([C:17]([NH:19][C:20]1[CH:33]=[CH:32][CH:31]=[CH:30][C:21]=1[C:22]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)=[O:23])=[O:18])[NH:6][C:7]([CH2:22][C:21]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:20]=1)=[O:9]

참가 물질

3

반응물 2

HCID 222Ammonia2회HCID 138095072-[N-(alpha-(Isopropylthio)-N-(benzyloxycarbonyl)-glycinyl)amino]benzophenone

생성물 1

HCID 543428902-[-(alpha-Amino-Nalpha-(benzylcarbonyl)glycinyl)amino]-benzophenone

실험 절차

The crude product 24 (9.3 g, 20.17 mmol) was dissolved in 133 mL of dry tetrahydrafuran. This solution was saturated with ammonia at 0° C. for 30 minutes and then mercuric chloride (6 g, 22.09 mmol) was added in one portion to the stirred solution while ammonia gas was bubbled through the solution. After bubbling ammonia gas for 2 hours at 0° C. it was bubbled for an additional hour at room temperature. The suspended solids were filtered and the solvent evaporated to yield 25 (9.7 g) which was used without further purification.

후처리

  1. customwas bubbled through the solution
  2. customAfter bubbling ammonia gas for 2 hours at 0° C. it
  3. customwas bubbled for an additional hour at room temperature
  4. filtrationThe suspended solids were filtered
  5. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-e5239504148e4eb3a00f638150a549b9
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05580979

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