Sulfuryl chloride → 3-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

HRID 1080401노트

반응식

HRID 1080401 반응식
[F:1][CH:2]([F:14])[O:3][C:4]1[N:8]([CH3:9])[N:7]=[C:6]([C:10]([O:12][CH3:13])=[O:11])[CH:5]=1.S(Cl)([Cl:18])(=O)=O>C(Cl)Cl>[Cl:18][C:5]1[C:6]([C:10]([O:12][CH3:13])=[O:11])=[N:7][N:8]([CH3:9])[C:4]=1[O:3][CH:2]([F:1])[F:14]

참가 물질

4

반응물 2

HCID 24648Sulfuryl chlorideHCID 54319416Methyl 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxylate

생성물 1

HCID 537351233-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2.1 g (10 mmol) 5-Difluoromethoxy-3-methoxycarbonyl1-methylpyrazole, dissolved in 30 ml methylene chloride, was treated with 1.35 g (10 mmol) sulfuryl chloride and the mixture stirred at room temperature for 10 minutes. It was then concentrated and the residue recrystallised from diisopropyl ether/ethyl acetate.

후처리

  1. concentrationIt was then concentrated
  2. customthe residue recrystallised from diisopropyl ether/ethyl acetate

출처 및 근거

ORD 기록
ord-6eeb597d50a84789af88a1fb009e2459
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05580986

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