2-(Ethoxymethylene)propanedinitrile → 5-Amino-4-cyano-1-(1-methyl-5-methylmercapto-3-pyrazolyl)pyrazole
반응식
[NH:1]([C:3]1[CH:7]=[C:6]([S:8][CH3:9])[N:5]([CH3:10])[N:4]=1)[NH2:2].C(O[CH:14]=[C:15]([C:18]#[N:19])[C:16]#[N:17])C>C(O)C>[NH2:19][C:18]1[N:1]([C:3]2[CH:7]=[C:6]([S:8][CH3:9])[N:5]([CH3:10])[N:4]=2)[N:2]=[CH:14][C:15]=1[C:16]#[N:17]참가 물질
4
실험 절차
A mixture of 2.0 g (13.1 mmol) 3-Hydrazino-1-methyl-5-methylmercaptopyrazole and 1.8 g (14.4 mmol) ethoxymethylenemalononitrile in 25 ml ethanol was stirred for 30 minutes at room temperature and heated at boiling point for 3 hours. The reaction mixture was concentrated and the residue purified by silica gel chromatography (hexane/ethyl acetate 1:1).
후처리
- temperatureheated
- customfor 3 hours
- concentrationThe reaction mixture was concentrated
- customthe residue purified by silica gel chromatography (hexane/ethyl acetate 1:1)
출처 및 근거
- ORD 기록
- ord-9d4d1597f2a5416ebbff189a0fb73877
- 출처 데이터셋
- uspto-grants-1996_12
- 특허 번호
- US05580986
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