홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Water → 2-Chloro-6-(1,2,3,4-tetrahydro-6,7-dimethoxyisoquinol-2-yl)purine

HRID 1080669
노트
인쇄 미리보기

반응식

HRID 1080669 반응식
Cl[C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[ClH:12].[CH2:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][NH:14]1.[CH2:23](N(CC)CC)C.[OH2:30].C[C:32](N(C)C)=[O:33]>>[Cl:12][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([N:14]2[CH2:15][CH2:16][C:17]3[C:22](=[CH:21][C:20]([O:33][CH3:32])=[C:19]([O:30][CH3:23])[CH:18]=3)[CH2:13]2)[N:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 5

HCID 962WaterHCID 8471TriethylamineHCID 31374DimethylacetamideHCID 27347171,2,3,4-Tetrahydroisoquinoline HydrochlorideHCID 53244122,6-Dichloropurine

생성물 1

HCID 233655362-Chloro-6-(1,2,3,4-tetrahydro-6,7-dimethoxyisoquinol-2-yl)purine수율 95%

실험 절차

A mixture of 5.67 g of 2,6-dichloropurine, 6.89 g of 1,2,3,4-tetrahydroisoquinoline hydrochloride and 6 g of triethylamine in 40 ml of dimethylacetamide was stirred under a nitrogen atmosphere at room temperature for 3.5 hours. The mixture was poured into 500 ml of water and stirred for 30 minutes. The solids were filtered, washed with water, pressed dry and stirred in hot methanol for 1 hour. The suspension was filtered while hot and the solids dried, 9.85 g (95% yield), m.p. 271°-276° C. dec.

후처리

  1. stirringstirred for 30 minutes
  2. filtrationThe solids were filtered
  3. washwashed with water
  4. custompressed dry
  5. stirringstirred in hot methanol for 1 hour
  6. filtrationThe suspension was filtered while hot and the solids
  7. customdried

출처 및 근거

ORD 기록
ord-3cd4e1fd30e64ab6b6a9a843b1a9cc45
출처 데이터셋
uspto-grants-1996_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05583137

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트