Triethylamine → 2-Chloro-6-(1,2,3,4-tetrahydro-6,7-dimethoxyisoquinol-2-yl)-7-methylpurine

HRID 1080672

반응식

HRID 1080672 반응식
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:11])[CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.Cl.[CH3:14][O:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][C:25]=1[O:26][CH3:27])[CH2:22][NH:21][CH2:20][CH2:19]2.C(N(CC)CC)C>C(Cl)Cl>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:11])[CH:7]=[N:8]2)=[C:4]([N:21]2[CH2:20][CH2:19][C:18]3[C:23](=[CH:24][C:25]([O:26][CH3:27])=[C:16]([O:15][CH3:14])[CH:17]=3)[CH2:22]2)[N:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 752812,6-dichloro-7-methyl-7H-purineHCID 64560356,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

생성물 1

HCID 233655202-Chloro-6-(1,2,3,4-tetrahydro-6,7-dimethoxyisoquinol-2-yl)-7-methylpurine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 1.44 g of 2,6-dichloro-7-methylpurine, 1.63 g of 1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline hydrochloride and 1.5 g of triethylamine in 25 ml of methylene chloride was stirred at room temperature under nitrogen for 15 hours. The reaction mixture was washed with a 1N hydrochloric acid solution (3×150 ml), water (3×150 ml) and a brine solution (1×100 ml), and then dried over sodium sulfate. Removal of the solvent left a residue which was chromatographed on 150 g of silica gel, 1.3 g.

후처리

  1. washThe reaction mixture was washed with a 1N hydrochloric acid solution (3×150 ml), water (3×150 ml)
  2. dry with materiala brine solution (1×100 ml), and then dried over sodium sulfate
  3. customRemoval of the solvent
  4. waitleft a residue which
  5. customwas chromatographed on 150 g of silica gel, 1.3 g

출처 및 근거

ORD 기록
ord-1f2a249a978e47ffa8903b89fa563290
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05583137

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