Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Azobisisobutyronitrile → Bromo(4-fluorophenyl)acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Azobisisobutyronitrile | HCID 6547 | — |
| 반응물 | 2-(4-Fluorophenyl)acetic acid | HCID 9837 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | Bromo(4-fluorophenyl)acetic acid | HCID 16217752 | — |
반응 단계
A solution of 4-fluorophenylacetic acid (9.7 g), N-bromosuccinimide (11.2 g) and azobisisobutyronitrile (AIBN, 0.2 g) in carbontetrachloride (100 ml) was reluxed for 2 hours. After cooling it was filtered through Celite® and the filtrate was evaporated to give an oily residue of α-bromo-4-fluorophenylacetic acid, which was used for next step without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05583147 |
| 출처 데이터셋 | uspto-grants-1996_12 |
| ORD ID | ord-4e825495e83c42d5bb09f376aa845f60 |
| 출처 메모 | uspto-grants-1996_12 |