Methanol → Methyl 2-bromo-2-(4-fluorophenyl)acetate

반응식

[Br:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4].[CH3:13]O>>[Br:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)[C:3]([O:5][CH3:13])=[O:4]

참가 물질

반응물 2

HCID 887Methanol

HCID 16217752Bromo(4-fluorophenyl)acetic acid

생성물 1

HCID 12717580Methyl 2-bromo-2-(4-fluorophenyl)acetate수율 87%

실험 절차

The α-bromo-4-fluorophenylacetic acid from Part 1 was dissolved in methanol (100 ml) and was added Dowex-50X-400® (2.7 g) to the solution. The mixture was refluxed for 6 hours and the resin was removed by filtering through Celite® after cooling. The filtrate was evaporated to give an oily residue, which was purified by column chromatography on silica gel with elution by 1:9 ethyl acetate-hexane to afford methyl α-bromo-4-fluorophenylacetate (87% yield).

후처리

additionwas added Dowex-50X-400® (2.7 g) to the solution
temperatureThe mixture was refluxed for 6 hours
customthe resin was removed
filtrationby filtering through Celite®
temperatureafter cooling
customThe filtrate was evaporated
customto give an oily residue, which
customwas purified by column chromatography on silica gel with elution by 1:9 ethyl acetate-hexane

출처 및 근거

ORD 기록: ord-f1c151c8a57848b3b032dbab0a2ec812
출처 데이터셋: uspto-grants-1996_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05583147

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