Methanol → Methyl alpha-oxo-2-thiopheneacetate

HRID 1080709노트

반응식

HRID 1080709 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:10])[C:7]([OH:9])=[O:8].[CH3:11]O>CCC(CCCCC(NC(C(NC(C(NC(C(NC1C(=O)NC(CCN)C(=O)NC(CC2C=CC=CC=2)C(=O)NC(CC(C)C)C(=O)NC(CCN)C(=O)NC(CCN)C(=O)NC(C(O)C)C(=O)NCC1)=O)CCN)=O)C(O)C)=O)CCN)=O)C.OS(O)(=O)=O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:10])[C:7]([O:9][CH3:11])=[O:8]

참가 물질

4

반응물 2

HCID 887MethanolHCID 776942-Thiopheneglyoxylic acid

생성물 1

HCID 11217486Methyl alpha-oxo-2-thiopheneacetate

시약·촉매·용매 1

HCID 5702105Aerosporin촉매

실험 절차

To a stirred solution of 2-thiopheneglyoxylic acid (1 g) in methanol (10 ml) was added 5 drops of concentrated sufuric acid and the mixture was refluxed for 4 hours. Then the methanol was evaporated off and the residue was partitioned between ethyl acetate and water. The organic extract was washed with water and brine, dried (sodium sulfate) and evaporated to give methyl 2-thiopheneglyoxylate as an oil (1.01 g).

후처리

  1. temperaturethe mixture was refluxed for 4 hours
  2. customThen the methanol was evaporated off
  3. customthe residue was partitioned between ethyl acetate and water
  4. extractionThe organic extract
  5. washwas washed with water and brine
  6. dry with materialdried (sodium sulfate)
  7. customevaporated

출처 및 근거

ORD 기록
ord-47a308e96fc2458889aa3190145ccd5c
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05583147

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