Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Naphthalenesulfonyl chloride → N-(2-naphthylsulfonyl)-glycine t-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Naphthalenesulfonyl chloride | HCID 7125 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Glycine tert-butyl ester hydrochloride | HCID 2725036 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(2-naphthylsulfonyl)-glycine t-butyl ester | HCID 19081114 | 87.3% |
반응 단계
14.4 ml of triethylamine are added dropwise to 6.91 g of glycine t-butyl ester hydrochloride and 12.1 g of 2-naphthylsulfonyl chloride in 70 ml of methylene chloride. The reaction mixture is subsequently diluted with 200 ml of ether. The organic phase is washed with 1N hydrochloric acid and with water. After drying and evaporation the residue is suspended in ether and suction filtered. After drying the crystals there are obtained 11.57 g of N-(2-naphthylsulfonyl)-glycine t-butyl ester, Rf=0.49 (ether/hexane 2:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05583133 |
| 출처 데이터셋 | uspto-grants-1996_12 |
| ORD ID | ord-5327e5da06f242eea1e62619c55768b1 |
| 출처 메모 | uspto-grants-1996_12 |