Sodium Carbonate → 2-(4'-Trifluoromethylphenyl)-6-hydroxybenzoxazole

HRID 1081229

반응식

HRID 1081229 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.[NH2:14][C:15]1[CH:21]=[CH:20][C:18]([OH:19])=[CH:17][C:16]=1O.C(=O)([O-])[O-].[Na+].[Na+]>>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]2[O:8][C:16]3[CH:17]=[C:18]([OH:19])[CH:20]=[CH:21][C:15]=3[N:14]=2)=[CH:5][CH:4]=1

참가 물질

4

반응물 3

HCID 10340Sodium CarbonateHCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 4328274-Aminoresorcinol

생성물 1

HCID 214669512-(4'-Trifluoromethylphenyl)-6-hydroxybenzoxazole

실험 절차

1.5 ml (10 mol) of 4-trifluoromethylbenzoyl chloride were heated to 190° C. in an oil bath and 1.6 g (10 mmol) of 4-aminoresorcinol were added in portions. After 1 hour the reaction mixture was introduced into 100 ml of 10% strength sodium carbonate solution and heated. The unreacted acid chloride was hydrolyzed during this procedure. The product was then extracted with ethyl acetate and purified by column chromatography (silica gel 60, ethyl acetate or chloroform/glacial acetic acid 9:1).

후처리

  1. temperatureheated
  2. extractionThe product was then extracted with ethyl acetate
  3. custompurified by column chromatography (silica gel 60, ethyl acetate or chloroform/glacial acetic acid 9:1)

출처 및 근거

ORD 기록
ord-163e225a31e2416b9769e2adc0f2e040
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05585247

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