Oxalyl chloride → 2,3,4,5-Tetrafluoro-6-methylbenzoyl chloride

HRID 1081391

반응식

HRID 1081391 반응식
[F:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[C:8]([F:13])=[C:7]([CH3:14])[C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C([Cl:18])=O>CN(C=O)C.ClCCl>[F:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[C:8]([F:13])=[C:7]([CH3:14])[C:3]=1[C:4]([Cl:18])=[O:5]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 129439972,3,4,5-Tetrafluoro-6-methylbenzoic acid

생성물 1

HCID 146512562,3,4,5-Tetrafluoro-6-methylbenzoyl chloride수율 98.6%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

A solution of 8.2 g (39.4 mmol) of 2,3,4,5-tetrafluoro-6-methylbenzoic acid, 6.0 g (47.2 mmol) of oxalyl chloride, and 100 mL of dichloromethane was treated with three drops of DMF. The solution was stirred for 3 hours, then concentrated to give 8.8 g of the title compound as a yellow liquid. The product was used as is in the next step.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5d05344005574118b5d716446c84e88d
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05585491

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