3-(p-Tolyl)acrylic acid → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(4-methylphenyl)ethenyl)-, (E)-

HRID 1081784노트

반응식

HRID 1081784 반응식
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH3:15][C:16]1[CH:26]=[CH:25][C:19]([CH:20]=[CH:21][C:22](O)=O)=[CH:18][CH:17]=1>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:22](/[CH:21]=[CH:20]/[C:19]3[CH:25]=[CH:26][C:16]([CH3:15])=[CH:17][CH:18]=3)=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

참가 물질

3

반응물 2

HCID 158353-(p-Tolyl)acrylic acidHCID 45721335,6-Diamino-1,3-diethyluracil

생성물 1

HCID 64488821H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(4-methylphenyl)ethenyl)-, (E)-수율 54%

실험 절차

Substantially the same procedure as in Example 7 was repeated using 3.00 g (15.1 mmol) of 5,6-diamino-1,3-diethyluracil and 2.70 g (16.7 mmol) of 4-methylcinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane to give 2.64 g (yield 54%) of Compound 106 as pale yellow needles.

후처리

  1. customThen, the resultant crude crystals were recrystallized from dioxane

출처 및 근거

ORD 기록
ord-c1b5e647c6cc4cd993f635d7d69a708f
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05587378

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