3-(3,5-Dimethoxyphenyl)-2-propenoic acid → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3,5-dimethoxyphenyl)ethenyl)-, (E)-

HRID 1081822노트

반응식

HRID 1081822 반응식
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH3:15][O:16][C:17]1[CH:18]=[C:19]([CH:25]=[C:26]([O:28][CH3:29])[CH:27]=1)[CH:20]=[CH:21][C:22](O)=O>>[CH3:29][O:28][C:26]1[CH:25]=[C:19]([CH:18]=[C:17]([O:16][CH3:15])[CH:27]=1)/[CH:20]=[CH:21]/[C:22]1[NH:1][C:2]2[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=2[N:8]=1

참가 물질

3

반응물 2

HCID 860923-(3,5-Dimethoxyphenyl)-2-propenoic acidHCID 45721335,6-Diamino-1,3-diethyluracil

생성물 1

HCID 64489061H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3,5-dimethoxyphenyl)ethenyl)-, (E)-수율 49%

실험 절차

Substantially the same procedure as in Example 7 was repeated using 3.00 g (15.1 mmol) of 5,6-diamino-1,3-diethyluracil and 3.48 g (16.7 mmol) of 3,5-dimethoxycinnamic acid. Then, the resultant crude crystals were recrystallized from ethanol/water to give 2.74 g (yield 49%) of Compound 130 as a white powder.

후처리

  1. customThen, the resultant crude crystals were recrystallized from ethanol/water

출처 및 근거

ORD 기록
ord-bdb9817dbab94e0291e8f205544a6195
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05587378

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