Imidazole → 2-Bromo-5-chloro-3-t-butyldimethylsilyloxy-methylbenzene
반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH2:4]O.N1C=CN=C1.[C:16]([Si:20](Cl)([CH3:22])[CH3:21])([CH3:19])([CH3:18])[CH3:17].CN(C=[O:28])C>CCOCC>[Br:1][C:2]1[C:9]([O:28][Si:20]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:22])[CH3:21])=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH3:4]참가 물질
6
실험 절차
To the solution of 2-bromo-5-chlorobenzylalcohol (10 g) from Example 73 and imidazole (3.23 g) in dry DMF (50ml) was added dropwise t-butyl chloro dimethylsilane in dry DMF (10 ml) for 20 minutes at -0° C. After addition, the mixture was stirred for 30 minutes at room temperature. The mixture was diluted with ether, and washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate.
후처리
- additionAfter addition
- washwashed with saturated sodium chloride solution
- dry with materialdried over anhydrous sodium sulfate
출처 및 근거
- ORD 기록
- ord-88b7559467854c518a0df0ac0ab495bd
- 출처 데이터셋
- uspto-grants-1996_12
- 특허 번호
- US05587392
반응 노트
불러오는 중…