Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 4,4-Dimethyl-2-(4'-chloromethylbiphenyl-2-yl)oxazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 4,4-Dimethyl-2-(4'hydroxymethylbiphenyl-2-yl)oxazoline | HCID 11065876 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4,4-Dimethyl-2-(4'-chloromethylbiphenyl-2-yl)oxazoline | HCID 10979477 | 98.7% |
반응 단계
1.0 g (3.55 mmol) of 4,4-dimethyl-2-(4'-hydroxymethylbiphenyl-2-yl)oxazoline was dissolved in methylene chloride (15 ml). Under cooling with ice, 0.51 g (4.29 mmol) of thionyl chloride was dropwise added thereto, followed by stirring for one hour. The reaction liquid was poured into an aqueous solution of sodium hydrogencarbonate, followed by the extraction with methylene chloride. After washing with water and drying, vacuum concentration was conducted. 1.05 g of the title compound was obtained as a crystal (yield 99%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05587504 |
| 출처 데이터셋 | uspto-grants-1996_12 |
| ORD ID | ord-f11cae4407fd4f299e36cf09b3bb6241 |
| 출처 메모 | uspto-grants-1996_12 |