2-Fluorobenzonitrile → 2-(4-Trifluoromethyl-2-aminophenylthio) benzonitrile

반응식

[CH:1]1[C:6]2[C:7](=S)[NH:8]C3C=CC=CC=3S[C:5]=2[CH:4]=[CH:3][CH:2]=1.Cl.[F:18][C:19]([F:29])([F:28])[C:20]1[CH:25]=[CH:24][C:23]([SH:26])=[C:22]([NH2:27])[CH:21]=1.FC1C=CC=CC=1C#N>CN(C=O)C>[F:29][C:19]([F:18])([F:28])[C:20]1[CH:25]=[CH:24][C:23]([S:26][C:5]2[CH:4]=[CH:3][CH:2]=[CH:1][C:6]=2[C:7]#[N:8])=[C:22]([NH2:27])[CH:21]=1

참가 물질

실험 절차

Using a procedure analagous to that of Example 3(a) and (b), 4-trifluoromethyl-2-aminothiophenol hydrochloride (11.48 g, 50 mmol) was combined with 2-fluorobenzonitrile in DMF solvent (100 ml) to give crude 2-(4-trifluoromethyl-2-aminophenylthio) benzonitrile (6.84 g). Hydrolysis and subsequent condensation gave the title compound as off-white crystals from ethanol (1.1 g, m.p. 233°-235° C., Rf 0.21, CH2Cl2 /MeOH 50:1).