Ammonia → 4-Methoxybenzamidine Hydrochloride

HRID 1082081

반응식

HRID 1082081 반응식
[ClH:1].CO[C:4](=[NH:13])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1.[NH3:14]>CO>[ClH:1].[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:4]([NH2:13])=[NH:14])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 12463133Methyl 4-methoxybenzimidate hydrochloride

생성물 1

HCID 123262194-Methoxybenzamidine Hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

35.9 g of 4-methoxybenzimidic acid methylester hydrochloride was dissolved in 300 ml of methanol. After saturation with ammonia gas under cooling in ice-water and stirring, the solution was stirred at room temperature for 15 hours. Then, methanol was evaporated in vacuo. Ethyl acetate was added to the residue. The precipitated crystals were filtered off and dried. Whereby 30.9 g of the desired substance was obtained as white crystals. Melting point is 220° to 221° C.

후처리

  1. stirringthe solution was stirred at room temperature for 15 hours
  2. customThen, methanol was evaporated in vacuo
  3. additionEthyl acetate was added to the residue
  4. filtrationThe precipitated crystals were filtered off
  5. customdried
  6. customWhereby 30.9 g of the desired substance was obtained as white crystals

출처 및 근거

ORD 기록
ord-3445fba12d2a4bb7b66b3f276e7d1fab
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05589477

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