Water → 2-(6-Azidopyrimidin-4-yloxy)ethanol
반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:8][CH2:9][CH2:10][OH:11])[CH:3]=1.[N-:12]=[N+:13]=[N-:14].[Na+].O>CN(C)C=O>[N:12]([C:2]1[N:7]=[CH:6][N:5]=[C:4]([O:8][CH2:9][CH2:10][OH:11])[CH:3]=1)=[N+:13]=[N-:14]참가 물질
5
반응 조건
- 온도
- 70 °C
실험 절차
To a solution of 2-(6-chloropyrimidin-4-yloxy)ethanol (5.61 g) in dimethylformamide (60 ml) is added sodium azide (4.18 g), and the mixture is stirred at 70° C. for 20 hours. After cooling, the reaction solution is treated with water, and extracted with ethyl acetate. The ethyl acetate layer is dried, and evaporated to remove the solvent. The residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate=1:1) to give 2-(6-azidopyrimidin-4-yloxy)ethanol (1.68 g).
후처리
- temperatureAfter cooling
- extractionextracted with ethyl acetate
- dry with materialThe ethyl acetate layer is dried
- customevaporated
- customto remove the solvent
- customThe residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate=1:1)
출처 및 근거
- ORD 기록
- ord-26c514975a574b5aa294bf0b1a9e1c82
- 출처 데이터셋
- uspto-grants-1996_12
- 특허 번호
- US05589478
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