참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl acetoacetate | HCID 7757 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 촉매 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Methyl 3-tetrahydropyrrolyl-2-butenoate | HCID 69630084 | 99.5% |
반응 단계
Methyl acetoacetate (20 g, 172.23 mmol) was dissolved in 250 mL of toluene, and then pyrrolidine (43 ml, 516.70 mmol) and p-toluenesulfonic acid hydrate (about 100 mg) were added dropwise. After installing a Dean-Stark separator to the reactor, the reaction mixture was refluxed 140° C. for two days, and then solvent was removed by concentrating the resulting mixture under a reduced pressure, thereby to obtain the desired product (29 g, 99%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07094908B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-8ef35b9c9c5c40bcabb7b408e1cb86f0 |
|---|
| 출처 메모 | uspto-grants-2006_08 |
|---|
